A clinical equivalence study is one where the aim is to show that the outcome for the two (or more) technologies studied differs by a clinically unimportant amount. These studies have similar rationales and characteristics to non-inferiority studies, except that the pre-specified equivalence margin ranges above and below the outcome value for the reference (comparator) intervention, and two-sided significance testing will generally be required. This more technical meaning of ‘clinical equivalence’ should not be confused with its more common use to denote that treatment options are considered to be equivalent (in efficacy, safety) by clinicians.

How to cite: Clinical Equivalence (Study) [online]. (2016). York; York Health Economics Consortium; 2016. https://yhec.co.uk/glossary/clinical-equivalence-study/