A mixed treatment comparison (MTC) is a statistical method that uses both direct evidence (from trials directly comparing the interventions of interest) and indirect evidence (from trials comparing each intervention of interest with a further alterative) to estimate the comparative efficacy and/or safety of interventions for a defined population. They are generalisations of traditional meta-analysis, and the analytical methods employed are now frequently referred to as ‘network meta-analysis’.


How to cite: Mixed Treatment Comparison [online]. (2016). York; York Health Economics Consortium; 2016. https://yhec.co.uk/glossary/mixed-treatment-comparison/